Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation. As such, P2X7 plays important roles in various inflammatory, immune, neurologic and musculoskeletal disorders. This review focuses on the ...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2019
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.9b00584